Outcome of Corneal Collagen Crosslinking for Progressive Keratoconus in Paediatric Patients
نویسندگان
چکیده
PURPOSE To evaluate the efficacy of corneal collagen crosslinking for progressive keratoconus in paediatric patients. METHODS This prospective study included 25 eyes of 18 patients (aged 18 years or younger) who underwent collagen crosslinking performed using riboflavin and ultraviolet-A irradiation (370 nm, 3 mW/cm2, 30 min). RESULTS The mean patient age was 14.3±2.4 years (range 8-17) and mean followup duration was 20.1±14.25 months (range 6-48). Crosslinked eyes demonstrated a significant reduction of keratometry values. The mean baseline simulated keratometry values were 46.34 dioptres (D) in the flattest meridian and 50.06 D in the steepest meridian. At 20 months after crosslinking, the values were 45.67 D (P=0.03) and 49.34 D (P=0.005), respectively. The best spectacle corrected visual acuity (BSCVA) and topometric astigmatism improved after crosslinking. Mean logarithm of the minimum angle of resolution (logMAR) BSCVA decreased from 0.24 to 0.21 (P=0.89) and topometric astigmatism reduced from mean 3.50 D to 3.25 D (P=0.51). CONCLUSIONS Collagen crosslinking using riboflavin and ultraviolet-A is an effective treatment option for progressive keratoconus in paediatric patients. Crosslinking stabilises the condition and, thus, reduces the need for corneal grafting in these young patients.
منابع مشابه
United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment.
PURPOSE To evaluate the safety and efficacy of corneal collagen crosslinking (CXL) for the treatment of progressive keratoconus. DESIGN Prospective, randomized, multicenter, controlled clinical trial. PARTICIPANTS Patients with progressive keratoconus (n = 205). METHODS The treatment group underwent standard CXL and the sham control group received riboflavin alone without removal of the e...
متن کاملRiboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus.
PURPOSE In animal eyes, a significant increase in corneal biomechanical stiffness has been found after collagen crosslinking by combined riboflavin/ultraviolet-A (UVA) treatment. The aim of the present study was to evaluate the clinical usefulness of riboflavin/UVA-induced collagen crosslinking for bringing the progression of keratoconus to a halt. DESIGN Prospective, nonrandomized clinical p...
متن کاملCorneal collagen crosslinking with riboflavin and ultraviolet-A light in progressive keratoconus: ten-year results.
PURPOSE To analyze the 10-year results of corneal collagen crosslinking (CXL) for keratoconus. SETTING Department of Ophthalmology, University Hospital, Dresden, Germany. DESIGN Retrospective interventional case series. METHODS The study included eyes treated for progressive keratoconus from 2000 to 2004. Corneal collagen crosslinking was performed by applying riboflavin and ultraviolet-A...
متن کاملComparative study of changes of corneal curvatures and uncorrected distance visual acuity prior to and after corneal collagen crosslinking: 1-year results
BACKGROUND/PURPOSE Keratoconus is the most common primary corneal ectatic disease and has considerable importance in public health. Corneal collagen crosslinking (CXL) is a procedure to mitigate progression of keratoconus and reduce demand for corneal transplantation. The aim of this study was to evaluate the effect of CXL on corneal topographic and uncorrected distance visual acuity (UDVA) by ...
متن کاملSterile Keratitis following Collagen Crosslinking
PURPOSE To report a keratoconic eye that developed severe sterile keratitis and corneal scar after collagen crosslinking necessitating corneal transplantation. CASE REPORT A 26-year-old man with progressive keratoconus underwent collagen crosslinking and presented with severe keratitis 72 hours after the procedure. The initial impression was infectious corneal ulcer and a fortified antibiotic...
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عنوان ژورنال:
دوره 2014 شماره
صفحات -
تاریخ انتشار 2014